Syllabus for CLBY/MBIO/BIOC 599 RNA Structure and Function Spring 2010

The class will meet Tuesdays and Thursdays 1-2:30 in RT 100-1

Date	Title	Instructor	References
Jan 19	Course Introduction and background lecture	Dr. Valadkhan	Mattick 2008, Nilsen 2007 also see this.  Download the Lecture
1	Lecture: Catalytic RNAs in viruses and eukaryotes, mechanism and in vivo relevance	Dr. Valadkhan	2007 review by Patel
26	Literature discussion by instructor	Dr. Valadkhan	2006 Szostak paper and commentary
28	Literature discussion by Vladimir Presnyak	Dr. Valadkhan	2009 Joyce paper
Feb 2	Lecture: RNA in biological processes: the role of RNA in telomerase, signal transduction particle, etc.	Dr. Gott	Review
4	Literature discussion by instructor	Dr. Gott	2009 paper by Li
9	Literature discussion by Matthew McPheeters	Dr. Gott	Strobel paper and a review
11	Lecture: Regulation by modulation of RNA structure: riboswitches and other elements.	Dr. deHaseth	2008 Henkin Review  and lecture slides
16	Literature discussion by instructor	Dr. deHaseth	Trans riboswitch paper
18	Literature discussion by Shuang Liang and Jessica Eisenstatt	Dr. deHaseth	Choose one of the three: RNaseY, GlmS, Pause inhibition
23	Lecture: RNA in disease, RNA therapeutics: antisense RNAs, ribozymes and small RNAs.	Dr. Bruzik	Darnell Review
25	Literature discussion by instructor	Dr. Bruzik	Discussion paper
Mar 02	Literature discussion by Jenna Sroka and Christine Petzold	Dr. Bruzik	Paper 1 and paper 2
4	Lecture: Long Non-protein coding RNAs, a novel class of regulators	Dr. Valadkhan	lncRNA review and paradigm shift review
16	Literature discussion by instructor	Dr. Valadkhan	Air RNA paper
18	Literature discussion by Yotam Blech-Hermoni	Dr. Valadkhan	Gas5 paper
23	Lecture: Ribosome as an RNA machine	Dr. Coller	Review
25	Literature discussion by instructor	Dr. Coller	Noller paper
30	Literature discussion by Melissa Babilonia	Dr. Coller	Paper 1 and paper 2
Apr 01	Lecture: miRNA function: an in-depth look	Dr. Nilsen	Reviews by Bartel,---Nilsen, Izaurralde----Filipowics,--- Cohen
6	Literature discussion by instructor	Dr. Nilsen	Paper 1 and paper 2 and supplementary data
8	Literature discussion by Trinh Tat and Rauli Jobava	Dr. Nilsen	paper 1 and paper 2 and sup1 and sup2 and commentary
13	Lecture: RNA structure and folding, RNA/RNA and RNA/protein interactions	Dr. Harris
15	Literature discussion by instructor	Dr. Harris
20	Literature discussion by Shikha Tandon	Dr. Harris
05/01/10	Exam: Mini-grant to be submitted by May 1st.	Graded by faculty	Example minigrant and evaluation sheet